Signature Serum

✓ 95% agreed skin felt soothed

The hero of the Dr Somji system. A multi-active daily antioxidant serum built around SOM1X®, our proprietary barrier-strengthening complex, to keep skin stable, supported and performing at its best.

Hydrating

RADIANCE-BOOSTING

RESILIENCE-BUILDING

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Free samples with every order

FREE UK SHIPPING OVER £60

Your skin isn't the same every day. It shifts with stress, hormones, the seasons, the products around it. What it needs is something consistent underneath all of that, a daily foundation it can rely on. That's what the Signature Serum was designed to be.

  • At the centre of the formula is SOM1X®, our proprietary complex developed exclusively with the Dr MediSpa clinical team. SOM1X® works at the level of the skin barrier: strengthening its structure, reducing moisture loss and supporting the skin's ability to regulate itself over time.

  • As part of the Dr Somji Protocol, it's formulated to be layered over any of our targeted Concentrates, amplifying their results and allowing you to personalise your routine as your skin's needs evolve.

  • Our Signature Serum has been trialled and tested in our Clinics, and developed specifically to work for post-procedure skin, to help reduce redness and hyperpigmentation. 

 

  • Pure Beauty 2024 - Best New Dermatological Treatment or Product. Formulated by Dr Munir Somji, Cosmetic Surgeon and Co-Founder of the award-winning Dr MediSpa Clinics.

  • 95% agree skin feels soothed
  • 90% said skin feels hydrated
  • 88% said skin feels moisturised
  • 87% agreed skin felt nourished

SOM1X®

Dr Somji's proprietary barrier-repair complex. Strengthens the skin barrier, reduces moisture loss and
supports long-term skin health.

Green Tangerine Exosomes

Biological nanoparticles sourced from Jeju Island, Korea. Higher Vitamin C content than lemons; rich in
anti-inflammatory Nobiletin. Drive hydration and renewal deeper into the skin, increasing Elastin and Hyaluronic Acid production.

Encapsulated Retinol

Controlled-release delivery, reducing irritation while maximising bioavailability. Increases Collagen 1 and
Elastin content, improving firmness and reducing fine lines.

Probiotics

Regulate microbiota pathways and restore the skin's instinctive defences.

Ceramides

Skin-identical ceramides in a bio-mimetic matrix. Repair and restore the protective skin barrier, enhancing
moisture and smoothness.

Encapsulated Multivitamins

Stabilised Vitamins F, A, C and E delivered to deeper skin layers. Battles oxidative stress and the appearance of premature ageing.

Aqua (Water), Propylheptyl Caprylate, Glycerin, Passiflora Edulis Seed Oil, Octyldodecanol, Inulin Lauryl Carbamate, Dimethyl Sulfone, Rosa Canina Fruit Oil, Xanthan Gum, Sorbitol, Sodium Pca, Maltodextrin, Copernicia Cerifera (Carnauba) Wax, Helianthus Annuus (Sunflower) Seed Oil, Sodium Lactate, Maris Aqua (Sea Water), Ribes Nigrum (Black Currant) Seed Oil, Citrus Reticulata (Tangerine) Fruit Extract, Citrus Reticulata (Tangerine) Fruit Juice Vesicles, Madecassoside, Lecithin, Retinol, Retinyl Palmitate, Ceramide Np, Ceramide Ap, Ceramide Eop, Tocopherol, Lactobacillus Ferment, Tocopheryl Acetate, Pogostemon Cablin Leaf Extract, Behenic Acid, Cholesterol, Helianthus Annuus (Sunflower) Seed Oil Unsaponifiables, Carnosine, Rosmarinus Officinalis (Rosemary) Leaf Extract, 3-O-Ethyl Ascorbic Acid, Phytosphingosine, Laminaria Digitata Extract, Cardiospermum Halicacabum Flower/Leaf/Vine Extract, Chondrus Crispus (Carrageenan) Extract, Chlorella Vulgaris Extract, Silybum Marianum Fruit Extract, Humulus Lupulus (Hops) Extract, Phenoxyethanol, Magnesium Aluminum Silicate, Caprylyl Glycol, Citronellyl Methylcrotonate, Polysorbate 20, Propanediol, Ethylhexylglycerin, Phytic Acid, Glyceryl Linoleate, Glyceryl Stearate, Glyceryl Linolenate, 1,2-Hexanediol, Glucose, Disodium Cocoamphodiacetate, Dehydroacetic Acid, Polyglyceryl-10 Stearate, Cetearyl Alcohol, Sodium Levulinate, Polyglyceryl-6 Behenate, Potassium Sorbate, Saccharide Isomerate, Triethyl Citrate, Ethyl Ferulate, Sodium Cetearyl Sulfate, Benzyl Alcohol, Benzoic Acid

What is SOM1X® and what makes it different?

SOM1X® is a proprietary barrier-repair complex developed exclusively by Dr Munir Somji and the Dr MediSpa clinical team. It works at the level of the skin's protective barrier — reinforcing its structure, reducing transepidermal moisture loss and supporting the skin's ability to regulate itself. What makes it particularly effective is its relationship with Encapsulated Retinol: by strengthening the barrier first, SOM1X® creates the environment for retinol to work at clinically active concentrations even on sensitive skin.

Can I use this if I have sensitive or reactive skin?

Yes. The Signature Serum is dermatologically tested and formulated to be suitable for sensitive skin. The encapsulated retinol in the formula is time-released to minimise irritation. If you have a significantly compromised barrier, consider using the Exosome Barrier Repair Serum first to build tolerance before introducing the Signature Serum.

When do I apply the Signature Serum in my routine?

Apply the Signature Serum as the second step, after your Concentrate (if using one) and before your SPF moisturiser in the morning, or Night Recovery Cream in the evening. It is designed to be layered over any of the four Concentrates — Anti-Wrinkle, Anti-Blemish, Anti-Redness, or Anti-Dark Spot.

Can I use the Signature Serum morning and evening?

Yes. It is formulated for twice-daily use. In the morning, follow with the Vitamin C Daily Defence SPF30. In the evening, follow with the Night Recovery Cream.

How long until I see visible results?

95% of trial participants reported soothed skin and 90% reported improved hydration within the 4-week trial period. Most users notice improved radiance and skin texture within 2–3 weeks. For firmness and barrier improvements, 4–8 weeks of consistent daily use is recommended.

Is this suitable for use during pregnancy?

The formula contains Encapsulated Retinol. We recommend consulting your GP or dermatologist before using retinol-containing products during pregnancy or breastfeeding.

Apply directly to cleansed face, neck and décolleté once or twice daily. If using a Concentrate, apply the Concentrate first, then follow with Signature Serum directly over the top.

Buy it with

 
Dr Somji Skincare

Dermatologically Tested

Dr Somji Skincare

Doctor Developed

Dr Somji Skincare

  Made in the UK

Dr Somji Skincare

Fragrance Free

Dr Somji Skincare

Cruelty Free

ACTIVE INGREDIENTS

Sourced from Jeju Island green tangerines — which contain more Vitamin C than lemons — these plant-derived biological nanoparticles penetrate the dermis to directly increase Elastin and Hyaluronic Acid production, redefining what topical hydration can achieve.

Using micro-encapsulation technology, retinol is time-released into the skin — bypassing surface irritation while delivering full bioavailability at depth. Clinically shown to increase Collagen 1 and Elastin for visible firmness and texture improvement.

A precision strain probiotic complex that rebalances the skin's microbiome at a genomic level — regulating the inflammatory pathways that drive sensitivity, dullness and accelerated ageing.

 PROPRIETARY BARRIER TECHNOLOGY

SOM1X®

Centella Leaf Extract, Marine Probiotics, Ceramides, MSM, Blackcurrant Seed Oil and Milk Thistle Extract work together to reinforce the skin's protective barrier, reduce moisture loss and support the skin's ability to regulate itself. Uniquely, SOM1X® creates the ideal environment for Encapsulated Retinol to deliver clinically active results — even on sensitive skin.

INDEPENDENT USER TRIALS

PROVEN RESULTS

95%

Agree skin feels soothed

90%

Said skin feels hydrated

88%

Said skin feels moisturised

OVERALL IMPROVEMENT IN SKIN QUALITY

VISIA imaging at 12 weeks shows firmer, brighter skin with improved evenness in both tone and texture.

COMPLETE YOUR ROUTINE

Targeted retinol and peptide treatment for fine lines.

The complete 5-step anti-ageing system.

Calm redness and rosacea with clinical exosome technology.

 
 
 

WHAT OUR CUSTOMERS SAY

"Gave my skin a radiance and glow"

"My skin looks and feels better and brighter"

"Makeup glides on nicely after use"

PRESS & EXPERT REVIEWS

"A lit-from-within glow I've never found in active skincare — and it acts as a beautiful face primer."

— Dani Guinsberg, Celebrity Makeup Artist

"I love the Signature Serum and the Vitamin C Daily Defence layered together — hydration, antioxidants, Vitamin C and sunscreen in just two products." 

— Sandra Cooke, Celebrity Makeup Artist

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  • 5 stars: 26 (100%)
  • 4 stars: 0 (0%)
  • 3 stars: 0 (0%)
  • 2 stars: 0 (0%)
  • 1 star: 0 (0%)
Some of the reviews shown are from related products the merchant grouped with this one.
A
Anonymous

It’s wonderfully light and hydrating. I use it as the first thing after toning and layer above with other serums or creams.

J
Julie

Lovely product. Feels amazing on the skin..My skin has never looked or felt so good.

S
Shirley K.

This serum is magical. It makes my skin look so smooth and polished. It lasts for ages.

V
Vicky L.

I have been using the Dr Somji Signature Serum for over a year now, and my skin has never looked and felt this good. The glow you get is unbelievable, and it has improved my skin texture so much, to a smooth and even tone. It most definitely helps smooth out and reduce fine lines, and redness which I’ve noticed the most. It is like magic in a bottle. But consistency is the absolute key I use mine day and night but a small bit goes a long way. I also mix a little bit in with my foundation on a night out and it gives you the best natural glow. One bottle last me a long time, you definitely get what you pay for. I team my serum with the nourishing cream cleanser and vitamin daily moisturiser. I also use the night recovery cream once a week. This combination is a miracle. This by far is the best cream and serum I have ever used, I’ve spent hundreds on creams in the past and never got the results I have now. My skin is healthy, clear and glowing thanks to DR Somji Skincare and I would never use anything else.

A
Anonymous

The signature serum is impeccable, I've been surveying from dry skin, tried lots of different products and this gave me a consistent hydrated look

J
Janki

Super gentle but seriously powerful. It’s a pleasure to use, and I noticed visible changes in just a few days, which almost never happens for me. Definitely one of the top skincare products I’ve used.

S
Sonali

Incredible product which I’ve been using daily for 3 months, it’s a hydrating product and my skin now glows! Cannot recommend this more highly!

A
Anonymous

So gentle, but oh so effective !
So nice to use. Started seeing improvement to already after a few days which isn’t standard for me! One of the best skin products I have ever used

D
Danielle S.

Love this serum! 🤍 It was recommended to me when I had a Hydrafacial and I was looking to refresh my skincare routine – and it’s honestly been the perfect addition. I’ve been using it for 8 months now!

My skin feels so much more hydrated and it gives me that gorgeous dewy glow without feeling heavy or sticky. It just sinks in beautifully and makes my skin look fresh and healthy.

If you’re thinking about updating your routine, I’d definitely recommend giving this a try

A
Anonymous

Love this serum makes my skin look great

Y
Yousra

The signature serum has my skin feeling smoother, more balanced, and deeply hydrated. The lightweight texture absorbs beautifully without feeling heavy or sticky, making it perfect under moisturiser or makeup.

C
Claudia F.

Best multi-task serum I’ve ever used! It does everything and keep my skin smooth, hydrated, tight and glowing. I love this product and I use it around the eyes as well. It is helping with the fine lines and dark circles. 5*

K
Katya T.

Love love love !
Cannot live without this product . I use it personally and will recommend to all of my clients and feedback is super positive.

D
Debra

I have been using the serum for a couple of weeks and can really see a difference in the fine lines around my mouth and chin

A
Ashleigh

Amazing serum, gentle but super effective and smells heavenly

L
Liene
53 Stars

I’m absolutely obsessed with this serum, it’s hands down one of the best I’ve ever used. My skin feels more hydrated, smoother, and visibly more radiant. I’ve been using it daily and I genuinely notice improvements in my skin tone, texture, and overall suppleness.

L
Lucy
50 Stars

Super Gentle yet so effective!
So nice to use. Started seeing improvement to already after a few days which isn’t standard for me! One of the best skin products I have ever used + Also a little goes a long way.

E
Elli H.
46 Stars

If you suffer with texture and uneven skin tone like me then I highly recommend this product. I feel my skin has improved massively. It really is a powerhouse in the skincare world and I can see why so many people recommended it to me. 10/10!! I combine this with the Anti Blemish. My skin therapist also uses this when I have microneedling and wow.... the glow is fantastic.

K
Krishna
42 Stars

I absolutely love this product. I’ve recently moved from using ZO Skin products to these and I have noticed a MASSIVE difference in my skin. I have never been complimented so much on my skin before. The cleanser is amazing and leaves my skin so clean and soft. The anti-redness and blemish serums really do work. The signature serum is amazing and leaves my skin so hydrated. The Vitamin c and SPF cream is so lovely as a daily cream and under my makeup and the night cream is so hydrating yet feels so light. I wake up with super glowy skin! My skin has never been more glowy and clear. Massively recommend every single product!!

J
Jennifer
40 Stars

I would recommend this serum to anyone with extremely acne prone and sensitive skin. I have battled with hormonal acne since my teenage years, this serum has significantly helped balanced the tone of my skin, made it feel smooth and helped reduce my acne.

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Elle
36 Stars

What a difference i have seen in my skin in such a short period of time! obsessed with this perfect product. You can use day or night which i love. Straight after use my skin feels silky smooth and has an immediate glow!

A
Anita S.l.
26 Stars

This serum has been made with love. It has all the actives you need without having to buy them separately. I am really looking forward for new products being added - I have the current ones. Highly recommend. Well done Dr Somji and his beautiful wife Henal!!!

E
Emma
25 Stars

Beautiful serum, not too heavy but still very hydrating. I love the fact that this has so many amazing active ingredients but doesn’t cause any adverse effects. This whole range is literally everything you would need for healthy, beautiful skin. I also use this as an eye cream!

H
Hayley S.
18 Stars

My new favorite serum and trust me I've tried a lot, love how light weight this feels on my skin. I use twice a day and since using can see an improvement - would highly recommend!

A
Anita
9 Stars

This serum worked wonders for me. I have been using it for two weeks and I can already see a difference. People have been complimenting me and asking what I have done!

A
Alex B.
6 Stars

Was lucky enough to get this serum as a preview in clinic and wow, I am so glad I have used it! I have used it with the Anti-Redness Concentrate to calm down redness which I get after exercise. This is cooling, and feels so gorgeous and silky on my skin. I’ve been using it for two weeks now and my skin feels calmer and looks more even. Can’t wait for further progress!